-Delile
- Yini i-allopurinol yezinja futhi yenzelwa ini?
- Kuzoze kube nini ukunikeza i-allopurinol inja?
- I-Allopurinol yezinja ezine-leishmania
- Imithamo ye-Allopurinol yezinja
- Imiphumela emibi ye-Allopurinol yezinja
- Ezinye izindlela ze-Allopurinol zezinja
I-Allopurinol umuthi osetshenziswa ekwelapheni komuntu ukwehlisa izinga le-uric acid ku-plasma nomchamo, ngoba ivimbela i-enzyme ethile ebandakanyeka ekwakhekeni kwayo. Kwezokwelapha izilwane, kuleli cala elithile ezinjeni, kungumuthi osetshenziswa ngokuhlangana nama-antimonials noma i-miltefosine ekwelapheni i-leishmaniasis.
Uma ufuna ukwazi kabanzi ngalo muthi, qhubeka ufunda le ndatshana ngabakwaPeritoAnimal, lapho sikhuluma khona nge- inja allopurinol, ukusetshenziswa kwayo, imithamo enconywayo nemiphumela engemihle engaba khona.
Yini i-allopurinol yezinja futhi yenzelwa ini?
I-Allopurinol iyi- i-enzyme inhibitor okuyinto, ikakhulukazi, evimbela i-enzyme eguqula ukuguqulwa kwe-xanthine ibe yi-uric acid. Ayisetshenziswa yodwa, kepha isebenza njengesengezeleli kumuthi oyinhloko we-leishmanicidal, i-antimony noma i-miltefosine, ukuzama ukuqeda ngokuphelele amagciwane kuzo zonke izicubu. Ngale ndlela, ukusetshenziswa kwe-allopurinol ezinjeni kuncishisiwe kwaba munye: ukwelashwa ngokumelene ne-leishmania.
Kuzoze kube nini ukunikeza i-allopurinol inja?
Lesi sidakamizwa senziwa ngomlomo kanye nokwelashwa kwaso ingahlala kusuka ezinyangeni eziyisithupha kuya onyakeni. Kukhona ngisho nezimo lapho ukwelashwa okude kusungulwa khona. Noma kunjalo, ukubuyekezwa nokulandelwa kwecala kuyadingeka ngemuva kokusungulwa kokwelashwa, kucatshangelwa ukuthi imvamisa yokubuyekezwa izokwakhiwa ngudokotela wezilwane, ngoba ngokobukhulu becala ngalinye kumele libekwe ngabodwana.
Ukwelashwa kwe-Allopurinol kufanele kuhambisane nesiguli. Isibonelo esisebenzayo kungaba yi-miltefosine nsuku zonke cishe inyanga engu-1, ihlanganiswe ne-allopurinol yansuku zonke cishe izinyanga eziyi-8.
I-Allopurinol yezinja ezine-leishmania
Njengoba sishilo esigabeni esedlule, i-allopurinol isetshenziselwa ukwelapha i-leishmania. ILeishmaniasis iyi- isifo se-parasitic kubangelwa i-protozoan edluliswa ukuluma kwe-vector: umiyane ondiza isihlabathi. Kuyisifo se-zoonosis sokusatshalaliswa komhlaba wonke kanye nesimo esibucayi, ngakho-ke, ngaphezu kwezindlela zokuvimbela ezisetshenziswayo ukunciphisa ukwanda kwaso (imigomo, amakhola oxosha amapayipi namaphayiphu, izivikeli mzimba), zonke izinja ezinesifo kufanele zilashwe.
Imidlwane egulayo yilezo ezinezimpawu zomtholampilo futhi ukutheleleka kwe-leishmania kuqinisekiswa ngokuxilongwa kwelabhorethri. Kuyisifo esingaqondile, okungukuthi, kungenzeka ngezimpawu zomtholampilo eziningi, ngakho-ke kubaluleke kakhulu ukuba nomlando omuhle we-epidemiology yendawo lapho kuhlala khona inja kanye nesimo sayo sokuvikelwa. Ezinye zalezi zimpawu yilezi: ama-dermatoses aqhaqazekile futhi anezilonda, ukukhubazeka, ukuphuma kwamakhala, ukuqina kwamakhala nangonyawo i-hyperkeratosis, ukukhathala, njll. Lesi sifo singahlukaniswa njenge-visceral noma i-leishmaniasis enqamulelayo.
Kuyinsakavukela ukuthi, ngaphezu kwe-leishmania, inja ihlushwa esinye isifo sesinanakazana esegazini njengoba sihlobene kakhulu nezinga lenja lokuvikela ukuqeda amagciwane. Ngakho-ke, kufanele siqale ukwelapha i-leishmaniasis lapho sinenja ezinzile, okungukuthi, uma lesi sifo sidale i-anemia, ukwehluleka kwezinso, i-dermatitis, njll., Kufanele siqale silaphe lezi zimo.
I-Miltefosine kanye nama-antimonials yimishanguzo ye-leishmanicidal (eqeda i-parasite) futhi isenzo sayo siyashesha futhi siba namandla, kuyilapho i-allopurinol iyi-leishmaniostatic (ivimbela ukuphindaphindwa kwesinanakazana). Ngalesi sizathu, kujwayelekile ukusebenzisa inhlanganisela yale mithi. Kodwa-ke, odokotela bezilwane abaningi bayathanda funa ezinye izindlela kunokusebenzisa i-allopurinol ngenxa yemiphumela emibi lo muthi onayo ezigulini.
Imithamo ye-Allopurinol yezinja
Umthamo we-allopurinol wezinja osungulelwe ukwelashwa kwe-leishmaniasis ngu 10 mg ngekhilogremu ngayinye yesisindo njalo emahoreni ayi-12, okusho ukuthi, kabili ngosuku.
Isethulo esivele sikhona semithi ngamaphilisi ane-100 mg kanye ne-300 mg ye-allopurinol. Ngakho-ke, udokotela wezilwane uzokutshela ukuthi mangaki amaphilisi okufanele uwasebenzise ngokwesisindo senja yakho. Futhi, khumbula ukuthi uchwepheshe unquma isikhathi sokwelashwa, okungafanele kumiswe ngaphandle kwemvume yabo yangaphambilini.
Imiphumela emibi ye-Allopurinol yezinja
Kunemiphumela emibi emibili eyinhloko i-allopurinol engayibangela ezinjeni ngesikhathi sokwelashwa:
- xanthinuria: lapho ama-purine ehliswa ama-enzyme ahambisanayo, i-xanthine iyakhiwa, futhi lokhu, kuguqulwa kube yi-uric acid. I-Allopurinol iphazamisa ukuguqulwa kwe-xanthine ibe yi-uric acid, okumele iqedwe emchameni, ikhiqize xanthine okweqile nokuqongelela okulandelanayo.
- I-Urolithiasis: ukweqiwa kwamakristalu e-xanthine kungakhiqiza ukuhlanganiswa ngezinto eziphilayo bese kwakhiwa ama-uroliths (amatshe). Lawa ma-urolith akhanyayo, okungukuthi, awabonwa nge-x-ray elula, futhi i-x-ray noma i-ultrasound ehlukile iyadingeka ukuyihlola.
Izimpawu zomtholampilo ezingabonwa ngalezi zifo zingokulandelayo:
- i-dysuria (ubuhlungu lapho uchama);
- hematuria (igazi umchamo);
- ukungakwazi ukubamba umchamo;
- ukuvinjelwa komchamo;
- ubuhlungu besisu.
Ungakuthola ukudla kwezinja okwenzelwe ngqo ukwelashwa kwe-leishmaniasis. Zibonakala ngokuqukethwe kwe-purine ephansi, okuvimbela ukwakheka kwamakristalu e-xanthine. Ngaphezu kwalokho, zinezinto ezisiza ukuvikela amalunga, isikhumba nokuzivikela komzimba.
Ezinye izindlela ze-Allopurinol zezinja
Njengoba sishilo ezigabeni ezedlule, imiphumela emibi ye-allopurinol iholele odokotela bezilwane abaningi ukuthi bakhethe ukufuna ezinye izindlela zalo muthi. Ngalo mqondo, ucwaningo lwamuva[1] iqinisekisa ukuthi i- engenamathambo, i-nutraceutical esekwe kwi-nucleotide iyasebenza uma kuqhathaniswa nokwanda kwe-leishmania futhi ayikhiqizi imiphumela engafuneki.
Umkhuba omusha wokwelashwa kwe-leishmania usiholela ekusebenziseni le mithi emisha engenayo imiphumela emibi. Okubi ukuthi lo muthi unezindleko eziphakeme uma kuqhathaniswa ne-allopurinol.
Lo mbhalo wenzelwe imininingwane kuphela, kwaPeritoAnimal.com.br asikwazi ukunquma ukwelashwa kwezilwane noma ukwenza noma yiluphi uhlobo lokuxilongwa. Siphakamisa ukuthi uthathe isilwane sakho uye kudokotela wezilwane uma kungenzeka ukuthi unanoma yiluphi uhlobo lwesimo noma ukungaphatheki kahle.
Uma ufuna ukufunda izindatshana eziningi ezifana ne- I-Allopurinol yezinja: imithamo nemiphumela emibi, sincoma ukuthi ufake isigaba semithi yethu.