Izimila zamangqamuzana amancane emakati - Izimpawu, ukwelashwa nokubikezela

-Delile

• Yini i-mast cell tumor emakati
• Izinhlobo zezicubu zeseli zesikhumba se-feline
• I-cutaneous mast cell tumor
• i-visceral mast cell tumor
• Izimpawu zezimila zamangqamuzana ezinamakati emakati
• Izimpawu zezicubu zesikhumba ezinqamulelayo emakati
• Izimpawu zezimila zeseli le-visceral mast emakati
• Ukuxilongwa kwe-feline mast cell tumor
• Ukuxilongwa kwe-mast cut cell tumor in amakati
• Ukuxilongwa kwama-visceral mast cell tumors emakati
• Ukwelashwa kwama-mast cell tumors emakati
• Ukwelashwa kwezicubu zesikhumba ezinqamulelayo emakati
• Ukwelashwa kwama-visceral mast cell tumors emakati

Izimila zamangqamuzana amancane emakati zingabonisa ngezindlela ezimbili ezihlukene: ukusika kanye ne-visceral. I-cutaneous mast cell tumor iyona evame kakhulu futhi uhlobo lwesibili lwe umdlavuza obulalayo kwande kakhulu emakati. Izicubu ze-visceral mast cell zenzeka ikakhulukazi ebuchosheni, noma kungenzeka futhi nakwezinye izindawo, njengamathumbu.

Ukuxilongwa kwenziwa nge-cytology noma i-biopsy ezimweni zezicubu zeseli zemisipha ezisikiwe, nange-cytology, ukuhlolwa kwegazi nokuxilongwa kwe-imaging kuma-visceral mast cell tumors. Ukwelashwa kwenziwa ngokuhlinzwa kuzo zombili lezi zimo, yize kungakhonjisiwe ezinhlotsheni ezithile zamathumba we-visceral mast cell, kungakhonjiswa, kusetshenziswa i-chemotherapy kanye nezidakamizwa ezisekelayo ukuthuthukisa ikhwalithi yempilo yamakati anezimila zeseli. Qhubeka ufunde le ndatshana yePeritoAnimal ukuze ufunde kabanzi mayelana isimila sesishukela, izimpawu zayo, ukwelashwa nokubikezela.

Yini i-mast cell tumor emakati

IMastocytoma ingenye yezinhlobo zamathumba ezingathinta amakati aqukethe i- ukubuyabuyelela kwe-mast cell ukubuyabuyelela. Amaseli amangqamuzana amangqamuzana aqhamuka emnkantsheni wethambo kusuka kwizandulela ze-hematopoietic futhi angatholakala esikhunjeni, ezicutshini ezihlangene, umgudu wamathumbu, nasemgudwini wokuphefumula.

Ingabe amaseli azivikelayo ulayini wokuqala omelene nezinto ezithathelwanayo nama-granules abo aqukethe izinto ezilamula ukusabela okwaliwa nokuvuvukala, okufana ne-histamine, i-TNF-α, i-IL-6, ama-protease, njll.

Lapho kwenzeka isimila salezi zingqamuzana, izinto eziqukethwe kumbumbu yazo zikhishwa ngendlela eyihaba, zibangele imiphumela yendawo noma yesistimu okungaholela kwizimpawu zemitholampilo ezahlukahlukene ngokuya ngendawo yazo.

Izinhlobo zezicubu zeseli zesikhumba se-feline

Emakati, izicubu ze-mast cell zingasikwa, lapho zitholakala esikhunjeni; noma i-visceral, lapho itholakala ku-viscera yangaphakathi.

I-cutaneous mast cell tumor

Kuyisigaxa sesibili esibi kaningi emakati kanye neyesine phakathi kwawo wonke amathumba esibindi. Amakati aseSiamese abonakala esengozini enkulu yokuhlushwa yizicubu zemast cell ezisikiwe. Zikhona izindlela ezimbili yamathumba amangqamuzana ama-cutaneous mast ngokuya ngezici zawo zomlando:

• imastocytosis: kwenzeka ikakhulukazi emakati angaphezu kweminyaka engu-9 ubudala futhi ihlukaniswa ibe yifomu elihlangene (okuvame kakhulu futhi kube nobungozi, kuze kufike kuma-90% wamacala) nefomu elenzekayo (elibi kakhulu, elingena ngaphakathi libangele imastastasis).
• Umlando: Kwenzeka phakathi kweminyaka emi-2 nengu-10 ubudala.

i-visceral mast cell tumor

Lezi zicubu zemast cell zingatholakala ku- izitho zomzimba njengo:

• Ubende (okuvame kakhulu).
• Amathumbu amancane.
• Ama-lymph node angaphakathi.
• Ama-lymph node kaMesenteric.

Ikakhulukazi kuthinta amakati amadala phakathi Uneminyaka engu-9 no-13 ubudala unkulunkulu.

Izimpawu zezimila zamangqamuzana ezinamakati emakati

kuya ngohlobo lwe i-feline mast cell tumor, izimpawu zingahluka, njengoba sizobona ngezansi.

Izimpawu zezicubu zesikhumba ezinqamulelayo emakati

Izicubu zesikhumba zemasikati ezisikwayo zingaba njalo uquqaba olulodwa noma oluningi (20% wamacala). Zitholakala ekhanda, entanyeni, esifubeni noma ezithweni, phakathi kokunye.

Iqukethe i- amaqhubu okuvame ukuthi:

• Kuchaziwe.
• 0.5-3 cm ububanzi.
• Hhayi i-pigmented noma i-pink.

Abanye izimpawu zomtholampilo okungabonakala endaweni yesimila yile:

• U-Erythema.
• Isilonda esikha phezulu.
• Ukulunywa okungapheli.
• Ukuzilimaza.
• Ukuvuvukala.
• I-edema engaphansi.
• Ukusabela kwe-Anaphylactic.

Amaqhuqhuva weseli yama-Histiocytic mast kuvame ukunyamalala ngokuzenzekelayo.

Izimpawu zezimila zeseli le-visceral mast emakati

Amakati anezicubu zeseli ze-visceral mast abonisa izimpawu ze izifo zesistimu, njengo:

• Ukuhlanza.
• Ukucindezeleka.
• I-Anorexia.
• Ukwehla kwesisindo.
• Uhudo.
• I-Hyporexia.
• Kunzima ukuphefumula uma kune-pleural effusion.
• I-Splenomegaly (usayizi wobende okhulisiwe).
• Ama-Ascites.
• I-hepatomegaly (isibindi esikhulisiwe).
• Ukushoda kwegazi (14-70%).
• I-Mastocytosis (31-100%).

Lapho ikati lethula izinguquko ebuchosheni, njengokukhuliswa, amaqhuqhuva, noma ukubandakanyeka komzimba jikelele, into yokuqala okufanele ucabange ngayo yisigaxa semast cell.

Ukuxilongwa kwe-feline mast cell tumor

Ukuxilongwa kuzoya ngohlobo lwe-mast cell tumor udokotela wezilwane asola ukuthi i-feline ingahle ihlupheke ngayo.

Ukuxilongwa kwe-mast cut cell tumor in amakati

Kusolwa izicubu zesikhumba semaski emakati emakati lapho kuvela i-nodule enezici ezichazwe ngenhla, iqinisekiswa yi-a i-cytology noma i-biopsy.

I-Histicitic mast cell tumor iyona enzima kakhulu ukuxilongwa yi-cytology ngenxa yezici zayo zeselula, imbudumbudu engacacile nokuba khona kwamaseli e-lymphoid.

Kumele kucatshangwe ukuthi, ku-feline eosinophilic granuloma, amaseli amangqamuzana nawo angavela, okungaholela ekutheni ukuxilongwa okungalungile.

Ukuxilongwa kwama-visceral mast cell tumors emakati

O ukuxilongwa umehluko Izicubu zeseli ze-feline visceral mast, ikakhulukazi lezo zobende, zifaka phakathi izinqubo ezilandelayo:

• Splenite.
• Ubende bokufinyelela.
• IHemangiosarcoma.
• I-hyperplasia engekho.
• I-Lymphoma.
• Isifo se-Myeloproliferative.

Ukubalwa kwegazi, ukuhlolwa kwamakhemikhali ezinto eziphilayo kanye nokuhlolwa kwe-imaging kubalulekile ekutholeni izicubu ze-visceral mast cell:

• Ukuhlolwa kwegazi: ekuhlolweni kwegazi, i-mastocytosis ne-anemia kungasolwa. Ikakhulukazi ukutholakala kwe-mastocytosis, okuyisici sale nqubo emakati.
• I-ultrasound yesisu: i-ultrasound ingathola i-splenomegaly noma isisindo samathumbu futhi ibheke ama-metastases kuma-mesenteric lymph node noma ezinye izitho ezinjengesibindi. Iphinde ikuvumela ukuthi ubone ushintsho ku-parenchyma yobende noma kumaqhuqhuva.
• i-x-ray yesifuba: I-CXR isivumela ukuthi sibheke isimo samaphaphu, sibheke ama-metastases, i-pleural effusion noma ushintsho ku-cranial mediastinum.
• I-Cytology: I-cytology yesifiso senaliti enhle ebuchosheni noma emathunjini ingahlukanisa isimila samangqamuzana kwezinye izinqubo ezichazwe ekuhlolweni okuhlukile. Uma kwenziwa kuketshezi lwe-pleural noma lwe-peritoneal, amaseli ama-mast nama-eosinophil angabonakala.

Ukwelashwa kwama-mast cell tumors emakati

Ukwelashwa okufanele kulandelwe kuzokwethula nokwehluka okuthile ngokuya ngohlobo lwe-mast cell tumor okufanele ilashwe.

Ukwelashwa kwezicubu zesikhumba ezinqamulelayo emakati

Ukwelashwa kwesikhumba semast cell esinqunyiwe kwenziwa nge ukuhlinzwa, noma ezimweni zezinhlobo ze-histiocytic, ezijwayele ukubuyela emuva ngokuzenzekelayo.

Ukuhlinzwa kuyelapha futhi kufanele kwenziwe ngokuthengiswa kwendawo kabusha, ezimweni zamaseli amangqamuzana, nangamamashi amabi kakhulu ezimeni ezisakazekayo. Ngokuvamile, i- ukususwa kwasendaweni ngamamajini aphakathi kuka-0.5 no-1 cm kuphakanyiswa noma yisiphi isimila sesikhumba se-mast esinqunyiwe esitholwe yi-cytology noma i-biopsy.

Ukuphindaphindeka kwezicubu zeseli zemisipha ezisikiwe akuvamile kakhulu, noma ekususweni okungaphelele.

Ukwelashwa kwama-visceral mast cell tumors emakati

THE ukususwa kokuhlinzwa we-visceral mast cell tumor yenziwa emakati enesisindo samathumbu noma ubende ngaphandle kwe-metastases kwenye indawo. Ngaphambi kokususwa, i- ukusetshenziswa kwama-antihistamine okufana ne-cimetidine noma i-chlorpheramine kunconywa ukunciphisa ubungozi bokuchithwa kwesitokisi samaseli, okungadala izinkinga ezinjengezilonda zesisu, ukujiya okungajwayelekile kanye ne-hypotension.

Isikhathi sokusinda esimaphakathi ngemuva kwe-splenectomy siphakathi Izinyanga eziyi-12 no-19, kodwa izici ezimbi zokubikezela zifaka phakathi amakati ane-anorexia, ukuncipha okukhulu kwesisindo, i-anemia, i-mastocythemia, ne-metastasis.

Ngemuva kokuhlinzwa, kuvame ukuphathwa i-chemotherapy ehambisanayo nge-prednisolone, i-vinblastine noma i-lomustine.

Ezimweni ze-metastasis noma ukubandakanyeka kohlelo, i-oral prednisolone ingasetshenziswa ngemithamo ye-4-8 mg / kg njalo ngamahora angama-24-48. Uma kudingeka i-ejenti eyengeziwe ye-chemotherapeutic, i-chlorambucil ingasetshenziswa ngomlomo ngomthamo ka-20 mg / m2 njalo emavikini amabili.

Ukwenza ngcono izimpawu zamakati athile, izidakamizwa ze-antihistamine ukunciphisa okweqile esiswini esiswini, isicanucanu kanye nengozi yesilonda emathunjini, i-antiemetics, izikhuthazi zesifiso sokudla noma ama-analgesics.

Manje njengoba usukwazi konke mayelana nezicubu zeseli ze-feline mast, siphakamisa ividiyo elandelayo mayelana nezifo ezivame kakhulu emakati:

Lo mbhalo wenzelwe imininingwane kuphela, kwaPeritoAnimal.com.br asikwazi ukunquma ukwelashwa kwezilwane noma ukwenza noma yiluphi uhlobo lokuxilongwa. Siphakamisa ukuthi uthathe isilwane sakho uye kudokotela wezilwane uma kungenzeka ukuthi unanoma yiluphi uhlobo lwesimo noma ukungaphatheki kahle.

Uma ufuna ukufunda izindatshana eziningi ezifana ne- Izimila zamangqamuzana amancane emakati - Izimpawu, ukwelashwa nokubikezela, sincoma ukuthi ufake isigaba sethu sezinye izinkinga zezempilo.